Colibactin
Chemical compound
Nº Q66363675 ★★★
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Colibactin
Chemical compound
Colibactin is a genotoxic metabolite produced by Escherichia coli and other Enterobacteriaceae. Colibactin is a polyketide peptide that can form inter-strand crosslinks in DNA. Colibactin forms DNA inter-strand cross-links by alkylation of adenine moieties on opposing DNA strands.
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From Wikipedia
Colibactin is a genotoxic metabolite produced by Escherichia coli and other Enterobacteriaceae. Colibactin is a polyketide peptide that can form inter-strand crosslinks in DNA. Colibactin forms DNA inter-strand cross-links by alkylation of adenine moieties on opposing DNA strands. It induces lytic development in certain bacteria that contain prophages. Colibactin is only produced by bacterial strains containing a polyketide synthase genomic island (pks) or clb biosynthetic gene cluster. About 20% of humans in high-income countries are colonized with E. coli that harbor the pks island.
Text: Wikipédia, CC BY-SA 4.0. · Image: Mftkoehler (CC BY-SA 4.0) ·
