Docusate

Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. Some studies state that docusate is not more effective than a placebo for improving constipation. Other docusate salts with medical use include those of calcium and potassium. Docusate salts are also used as food additives, emulsifiers, dispersants, and wetting agents, among other uses. It is on the World Health Organization's List of Essential Medicines. In 2023, it was the 148th most commonly prescribed medication in the United States, with more than 3 million prescriptions. In 2023, the combination with senna was the 242nd most commonly prescribed medication in the United States, with more than 1 million prescriptions.