Flumazenil
Chemical compound
Nº Q421920 ★★
Uncommon · Knowledge
Flumazenil
Chemical compound
Flumazenil, also known as flumazepil, is a selective GABAA receptor antagonist administered via injection, or intranasally. Therapeutically, it acts as both an antagonist and antidote to benzodiazepines (particularly in cases of overdose), through competitive inhibition.
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From Wikipedia
Flumazenil, also known as flumazepil, is a selective GABAA receptor antagonist administered via injection, or intranasally. Therapeutically, it acts as both an antagonist and antidote to benzodiazepines (particularly in cases of overdose), through competitive inhibition. It was first characterized in 1981, and was first marketed in 1987 by Hoffmann-La Roche under the trade name Anexate. However, it did not receive FDA approval until December 1991. The developer lost its exclusive patent rights in 2008 and generic formulations are available. Intravenous flumazenil is primarily used to treat benzodiazepine overdoses and to help reverse anesthesia. Administration of flumazenil by sublingual lozenge and topical cream has also been tested.
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