Common · Knowledge
Metalloproteinase
Class of enzymes
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis. Most metalloproteases require zinc, but some use cobalt.
From Wikipedia
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis. Most metalloproteases require zinc, but some use cobalt. The metal ion is coordinated to the protein via three ligands. The ligands coordinating the metal ion can vary with histidine, glutamate, aspartate, lysine, and arginine. The fourth coordination position is taken up by a labile water molecule. Treatment with chelating agents such as EDTA leads to complete inactivation. EDTA is a metal chelator that removes zinc, which is essential for activity. They are also inhibited by the chelator orthophenanthroline.
Text: Wikipédia, CC BY-SA 4.0. · Image: Jawahar Swaminathan and MSD staff at the European Bioinforma... (Public domain) ·
Related cards
-
★
Metalloprotein
Protein that contains a metal ion cofactor
-
M★
Matrix metalloproteinase
Family of zinc-dependent metalloendopeptidases that is involved in the degradation of the extracellular matrix
-
★★
Protease
Enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids
-
★
Adenosine deaminase
Mammalian protein found in Homo sapiens
-
C★
Collagenase
Class of enzymes
-
P★
Permease