Sanguinaria

Sanguinaria canadensis, bloodroot, is a perennial, herbaceous flowering plant native to eastern North America. It is the only species in the genus Sanguinaria, included in the poppy family Papaveraceae, and is most closely related to Eomecon of eastern Asia. Sanguinaria canadensis is sometimes known as Canada puccoon, bloodwort, redroot, red puccoon, and black paste. Plants are variable in leaf and flower shape, and have been separated as a different subspecies due to these variable shapes, indicating a highly variable species. In bloodroot, the sap is red and poisonous. Products made from sanguinaria extracts, such as black salve, are escharotic and can cause permanent disfiguring scarring. If applied to the skin, the extract sanguinarine may cause a massive scab of dead flesh where it killed the cells, called an eschar. Although there are laboratory studies indicating that sanguinaria may have potential in cancer therapy, clinical studies are lacking, and use is not recommended due to significant off-target toxicity.