James O'Neill

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James O'Neill is an American science and technology investor who was U.S. Deputy Secretary of Health and Human Services from June 2025 to February 2026, and concurrently acting Director of the Centers for Disease Control and Prevention from August 2025 to February 2026. O'Neill served in several roles at the U.S. Department of Health and Human Services during the Bush administration during 2002–2008, the most senior of which was Principal Associate Deputy Secretary. He subsequently was a managing director at Clarium Capital and then at Mithril Capital. He then was CEO of SENS Research Foundation, a medical research organization focused on rejuvenation. He has been a frequent critic of the U.S. Food and Drug Administration. In 2025, President-elect Donald Trump nominated O'Neill to serve as U.S. Deputy Secretary of Health and Human Services. He was confirmed along party lines by a 52–43 vote, and assumed office on June 9, 2025. Later that year, O'Neill was concurrently appointed as acting director of the Centers for Disease Control and Prevention. He left his HHS positions on February 13, 2026, and was then nominated to be the director of the National Science Foundation on March 2, 2026.