MDM2

Gène de l'espèce Homo sapiens

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor.

Nº Q18028978 ★

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MDM2

Gène de l'espèce Homo sapiens

Texte en anglais

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor.

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Texte en anglais Pas encore d'article dans ta langue : extrait en anglais.

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation. The mdm2 gene is an oncogene, and increased levels of the protein have been found in several types of human tumors, including sarcomas and breast tumors.

Texte : Wikipédia en anglais, CC BY-SA 4.0. · Image : TimVickers at English Wikipedia (Public domain) ·

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