6-Methylnicotine

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6-Methylnicotine (6-MN) is a nicotine analogue in which a methyl group is added at the 6-position of the pyridine ring. It has been identified in certain electronic cigarettes and oral pouch products marketed as nicotine alternatives, sometimes under the trade names Metatine (in disposables) and Nixodine-S (sold as a benzoate salt or free base). Studies in cells, animal models, and early human biomonitoring indicate higher activity at nicotinic acetylcholine receptors and differences in toxicity and metabolism compared with nicotine. Although sometimes marketed as "not made or derived from tobacco", a 2025 analytical study reported trace natural occurrence of 6-MN in tobacco at a mean of 0.32 micrograms per gram (μg/g) and detected low-μg/mL levels in some previously analysed high-nicotine e-liquids, complicating origin-based regulatory claims.