methylisothiazolinone

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Methylisothiazolinone (/ˌmɛθəlˌaɪsoʊˌθaɪ.əˈzoʊlɪnoʊn/), MIT, or MI, is the organic compound with the formula S(CH)2C(O)NCH3. It is a white solid. Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications. MIT and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis. It is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide: The crystal and molecular structure of methylisothiazolinone, as determined by in situ cryocrystallography, was reported for the first time in 2024. Methylisothiazolinone is used for controlling microbial growth in water-containing solutions. It is typically used in a formulation with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5 to 15% of CMIT/MIT. Kathon also has been used to control slime in the manufacture of paper products that contact food. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food.