Monodnaviria

EN Texto em inglês Ainda não há artigo no seu idioma: trecho em inglês.

Floreoviria is a realm of eukaryotic viruses that contains all viruses that encode a replication protein that has an N-terminal HUH superfamily endonuclease domain and a C-terminal superfamily 3 helicase domain, as well as all viruses descended from such viruses. Floreovirians typically have circular single-stranded DNA (ssDNA) genomes, but some have linear ssDNA genomes or circular double-stranded DNA (dsDNA) genomes. The prototypical members of the realm are commonly called CRESS-DNA viruses, which stands for circular, Rep-encoding ssDNA viruses. The replication (Rep) protein is involved in initiating replication of viruses in Floreoviria. Along with the shared replication protein, most floreovirians encode a major capsid protein (MCP) characterized by a single jelly roll motif. The MCP is the primary component of the capsid, a protein shell that surrounds the genome. Floreovirian extracellular bodies (virions) consist of the genome and the capsid, which is icosahedral in shape. Circular ssDNA viruses in the realm replicate through rolling circle replication, and the dsDNA viruses in the realm use bidirectional theta replication. Among linear ssDNA viruses in the realm, parvoviruses use rolling hairpin replication, whereas bidnaviruses encode a protein-primed DNA polymerase that performs replication. Floreovirians are believed to be descended from bacterial plasmids that encode the hallmark replication protein of the realm. These plasmids recombined with RNA viruses to obtain capsid proteins. The linear ssDNA and circular dsDNA viruses in the realm are descended from CRESS-DNA viruses. Floreovirians are associated with many diseases in their hosts. Examples include geminiviruses, which cause disease economically important crops, and papillomaviruses, which cause cancers. Anelloviruses, which are ssDNA viruses, infect humans but are not associated with symptoms, an example of commensalism in which they replicate without having an effect on their host. Some floreovirians may become integrated into the genome of their host, such as adeno-associated virus, which is used...