Mitochondria

A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. The term mitochondrion, meaning "a thread-like granule", was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase popularized by Philip Siekevitz in a 1957 Scientific American article of the same name. Mitochondria are commonly between 0.75 and 3 μm2 in cross section, but vary considerably in size and structure. Unless specifically stained, they are not visible. The mitochondrion is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, intermembrane space, inner membrane, cristae, and matrix. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth. Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. Mitochondria are implicated in human disorders and conditions such as mitochondrial diseases, cardiac dysfunction, heart failure, and autism. The number of mitochondria in a cell varies widely by organism, tissue, and cell type. A mature red blood cell has no mitochondria, whereas a liver cell can have more than 2000. Although most of a eukaryotic cell's DNA is contained in the cell nucleus, the mitochondrion has its own genome ("mitogenome") that is similar to bacterial genomes. This finding has led to general acceptance of symbiogenesis (endosymbiotic theory) – that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past,...