Cychlorphine

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Cychlorphine is a synthetic opioid chemical compound which has been sold as a designer drug, cited in several autopsies, and reported in five European countries since 2024, in the United States, and in Canada in 2025. It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine have been published. It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine. Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses. In July 2026 the Dutch health authority were using Naloxone as an immediate treatment, antidote and help with breathing.