dimetindene
Médicament
Nº Q426070 ★★★
Rare · Savoirs
dimetindene
Médicament
Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation selective H1 antagonist. Dimetindene is an atypical first generation H1 antagonist as it only minimally passes across the blood–brain barrier, and has no sedating effect after a single dose.
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Prix plancher
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Médiane 7 j
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Ventes 30 j
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Fourchette 30 j
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- Dernière vente
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- Moyenne 30 j
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- Plus bas 30 j
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- Ventes 7 j
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- Ventes 30 j
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Sur Wikipédia
Texte en anglais Pas encore d'article dans ta langue : extrait en anglais.
Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation selective H1 antagonist. Dimetindene is an atypical first generation H1 antagonist as it only minimally passes across the blood–brain barrier, and has no sedating effect after a single dose. (S)-(+)-dimetindene is also a strong M2 receptor antagonist, with this enantiomer being more potent (up to 41-fold) for all muscarinic receptors assayed. The (R)-(-)-enantiomer is the eutomer regarding the H1 receptor ((R)-isomer pA2 = 9.42; (S)-isomer pA2 = 7.48). It was patented in 1958 and came into medical use in 1960.
Texte : Wikipédia en anglais, CC BY-SA 4.0. · Image : Fvasconcellos 15:30, 15 July 2007 (UTC) (Public domain) ·
