Dizocilpine

Chemical compound

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions.

Nº Q4386371 ★

Common · Knowledge

Dizocilpine

Chemical compound

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions.

From Wikipedia

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions. Dizocilpine is also associated with a number of adverse psychological reactions, including cognitive disruption and psychotic-spectrum reactions. By inhibiting long-term potentiation, dizocilpine impairs learning and memory in rodent and primate models. Due to safety issues, dizocilpine remains a tool in scientific research, rather than a clinical medicine. Dizocilpine also has activity at nicotinic acetylcholine receptors, as well as serotonin and dopamine transporters.

Text: Wikipédia, CC BY-SA 4.0. · Image: Fvasconcellos (Public domain) ·

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