Dizocilpine

Chemical compound

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions.

Nº Q4386371 ★

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Dizocilpine

Chemical compound

Texte en anglais

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions.

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Texte en anglais Pas encore d'article dans ta langue : extrait en anglais.

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions. Dizocilpine is also associated with a number of adverse psychological reactions, including cognitive disruption and psychotic-spectrum reactions. By inhibiting long-term potentiation, dizocilpine impairs learning and memory in rodent and primate models. Due to safety issues, dizocilpine remains a tool in scientific research, rather than a clinical medicine. Dizocilpine also has activity at nicotinic acetylcholine receptors, as well as serotonin and dopamine transporters.

Texte : Wikipédia en anglais, CC BY-SA 4.0. · Image : Fvasconcellos (Public domain) ·

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