Dizocilpine

Chemical compound

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions.

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Dizocilpine

Chemical compound

Texto en inglés

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions.

En Wikipedia

Texto en inglés Aún no hay artículo en tu idioma: extracto en inglés.

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, discovered by a team at Merck in 1982. The drug acts as a potent anticonvulsant and dissociative agent, but is not used clinically due to an adverse safety profile. In laboratory rats, the drug induces Olney's lesions. Dizocilpine is also associated with a number of adverse psychological reactions, including cognitive disruption and psychotic-spectrum reactions. By inhibiting long-term potentiation, dizocilpine impairs learning and memory in rodent and primate models. Due to safety issues, dizocilpine remains a tool in scientific research, rather than a clinical medicine. Dizocilpine also has activity at nicotinic acetylcholine receptors, as well as serotonin and dopamine transporters.

Texto: Wikipedia en inglés, CC BY-SA 4.0. · Imagen: Fvasconcellos (Public domain) ·

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